Oleic acid: An efficient inhibitor of glucosyltransferase

Won, Se-Ra; Hong, Mi-Jung; Kim, Yong-Mu; Li, Chun Ying; Kim, Jang-Won; Rhee, Hae-Ik

doi:10.1016/j.febslet.2007.09.045

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Oleic acid: An efficient inhibitor of glucosyltransferase

Won, Se-Ra;
Hong, Mi-Jung;
Kim, Yong-Mu;
Li, Chun Ying;
Kim, Jang-Won;
외 1명

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초록

Among the extracts from 420 kinds of herbs, Prunus salicina, showing the highest glucosyltransferase inhibition activity, was purified and designated GTI-0163. Structural determination of GTI-0163 revealed it to be an oleic acid-based unsaturated fatty acid. GTI-0163 was an uncompetitive inhibitor of GTase. Among the unsaturated fatty acids, oleic acid showed a significantly higher GTase inhibitory activity than the saturated fatty acids or the ester form of oleic acid. These results strongly suggested that both the number of double bonds and the existence of free carboxyl groups of fatty acids play an important role in GTase inhibitory activity. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

키워드

GTase inhibitor; oleic acid; dental caries; Prunus salicina; STREPTOCOCCUS-MUTANS; ANTIBACTERIAL ACTIVITY; IN-VITRO; SOBRINUS; POLYPHENOLS; PROPOLIS; EXTRACT

제목: Oleic acid: An efficient inhibitor of glucosyltransferase

저자: Won, Se-Ra; Hong, Mi-Jung; Kim, Yong-Mu; Li, Chun Ying; Kim, Jang-Won; Rhee, Hae-Ik

DOI: 10.1016/j.febslet.2007.09.045

발행일: 2007-10-16

유형: Article

저널명: FEBS Letters

권: 581

호: 25

페이지: 4999 ~ 5002