Arginase II Inhibitory Activity from Crude Drugs

초록

Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. In our experiment, the EtOH extracts of four-hundreds extracts drugs were investigated for the arginase inhibitory activity. Among them, four extracts exhibited over 50% inhibition of arginase II activity compared to control at a concentration of 150 mg/mL. In particular, the seed of Arctium lappa, gum-resin of Boswellia carterii, aerial part of Artemisia apiacea and rhizome of Cyperus rotundus inhibited arginase II activity, with IC50 values of 118.4, 135.4, 123.9 and 86.7 mg/mL, respectively. In addition, four plant extracts showed less than 20% inhibition of arginase I activity at 150 mg/mL. These plants might be the potential candidate materials in the development of the novel atherosclerosis drug.

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