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초록
The effect of cocaine on reproductive system were studied in male ICR mice. Daily injection of cocaine HCl (10, and 40 mg/kg, s.c. for 15 days) disrupted epididymal sperm levels and testicular morphology. These disruptions were manifested in a decreased number of sperm, an increased number of dead sperm as compared with control vehicle, and were evidenced by vacuolations, multinucleated giant cell formations and coagulation necrosis in the testicular seminiferous tubules. Responses in the current study were trended in dose dependent pattem. These results suggest that chronic cocaine intoxication can perturb on male reproductive organ functioning. © 1994 The Pharmaceutical Society of Korea.
키워드
Chronic cocaine intoxication; coagulation necrosis; epididymal sperm level; reproductive organ functioning; testicular morphology
- 제목
- Testicular degeneration and sperm loss induced by chronic administration of cocaine in mice
- 저자
- Suh, Jeong-hye; Yang, Bookeun; Lim, Dongkoo; Jhoo, Wang-kee; Kim, Hyoung-chun
- 발행일
- 1994
- 유형
- Article
- 권
- 17
- 호
- 4
- 페이지
- 213 ~ 217