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Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
- Han, Sun-Young;
- Choi, Jie Won;
- Yang, Jeon;
- Chae, Chong Hack;
- Lee, Jongkook;
- 외 5명
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38Citations
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39초록
A series of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones have been identified as a new class of VEGFR-2 kinase inhibitors. A variety of (4,5,6,7-tetrahydro-imidazo[5,4-c]pyridin-2-yl)-acetic acid ethyl esters were synthesized, and their VEGFR-2 inhibitory activity was evaluated. Described herein are the preparation of the series and the effects of the compounds on VEGFR-2 kinase activity. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Cancer; VEGFR-2; KDR kinase; Imidazo[4,5-c]pyridine; Quinolin-2-one; ENDOTHELIAL GROWTH-FACTOR; ORAL MULTIKINASE INHIBITOR; CANCER-THERAPY; ANGIOGENESIS; BEVACIZUMAB; PHARMACOKINETICS; NAPHTHAMIDES; RECEPTORS; SUNITINIB; ANTIBODY
- 제목
- Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
- 저자
- Han, Sun-Young; Choi, Jie Won; Yang, Jeon; Chae, Chong Hack; Lee, Jongkook; Jung, Heejung; Lee, Kwangho; Ha, Jae Du; Kim, Hyoung Rae; Cho, Sung Yun
- 발행일
- 2012-04-15
- 유형
- Article
- 권
- 22
- 호
- 8
- 페이지
- 2837 ~ 2842
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 6 페이지
- ISSN
- E 1464-3405
P 0960-894X