Evaluation of the effect of kaempferol in a murine allergic rhinitis model

초록

Kaemplerol (KR) is a major compound of Naju jjok (Polygonum tinctoriurn Lour.). The effect of KR on allergic rhinitis (AR) has not been elucidated. Here, we report the effects and mechanisms of KR On new and predominant mediators of AR using an eosinophil cell line, Eol-1 and an ovalbumin (OVA)-induced AR mouse model. KR significantly inhibited the production of interleukin (IL)-32 and IL-8 and activation of caspase-1 in Eol-1 cells. Allergic symptoms and predominant mediators (lgE and histamine) in the KR-administered group were significantly lower than in the AR group. The levels of interferon-1 were enhanced while the levels of IL-4 were reduced in the KR group. KR significantly reduced the levels of IL-32 and thymic stromal lymphopoietin (TSLP) compared with the AR mice. KR reduced the levels of inflammation-related proteins. In the KR-administered groups, the infiltrations of eosinophils and mast cells increased by OVA were decreased. In addition, KR significantly reduced caspase-1 activity in nasal mucosa tissue of AR mica Our findings indicate that KR has an anti-allergic effect through the regulation of the production of IL-32 and TSLP and caspase-1 activity in allergic diseases including AR. (C) 2013 Elsevier B.V. All rights reserved.

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