단백질체학을 활용한 신약 개발 연구

초록

One of the most promising developments to come from the study of human genes and proteins has been the identification of potential new drugs for the treatment of disease. This relies on genome and proteome information to identify proteins associated with a disease, which computer software can then use as targets for new drugs. If a certain protein is implicated in a disease, the 3D structure of that protein provides the information a computer programs needs to design drugs to interfere with the action of the protein. Proteomics, the study of the proteins and protein pathways involved in disease, is a promising tool for new drug discovery, which aim to find new drugs to inactivate proteins involved in disease. As genetic differences among individuals are found, researchers will use these same techniques to develop personalized drugs that are more effective for the individual. With recent advances in the field of proteomics, microarrays(biochips), HCS(high contents screening), cGMP(current Good Manufacturing Practice) technology have readily been adapted to proteomics applications. Using this tool, global proteome analysis and protein expression profiling will thus provide new opportunities for biomarker discovery, drug target identification and disease diagnostics, as well as providing insights into disease biology. Proteomics as a whole increasingly plays an important role in the multi-step drug-development process. In this review, the current status and methods of proteomics technology and some applications are briefly described. Additionally, this review discusses some of the recent research and market trends in proteomics.

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