DIS에 의한 Polyethylene Glycol 함침 알로에 베라 겔의 보습 및 경피흡 수 특성

초록

This study was carried out to investigate the in vitroand in vivo moisturizing properties and percutaneous absorptionof PEG-impregnated Aloe vera gel. The PEG-i-Aloe gelwas obtained from dewatering and impregnation by soaking(DIS) of Aloe vera leaf slice. The moisturizing property of theobtained sample was evaluated by moisture determinationusing gravimetric method in desiccator under different RH%and by water sorption-desorption test on human skin. The transdermalpenetration characteristics of PEG-i-Aloe gel was investigatedby Franz diffusion cell in vitro transdermal absorptionmethod. PEG-i-Aloe gel had high moisture retention abilityand could significantly lead the enhancing skin hydrationstatus as well as reducing the skin water loss due to the filmformation as a skin barrier. The skin penetration rate of PEGi-Aloe gel at steady state was 9.76 μg/(h·cm2) and the quantityof the transdermal absorption was 144 μg/cm2 in 9 hr. Thepenetration mechanism was well fitted with Higuchi model(R2 = 0.974−0.994). The results show that PEG-i-Aloe gel hasthe significant moisturizing effect and strong penetration ofthe animal skin. It could be used as the moisturizing additivein cosmetic skin products.

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