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A new anti-inflammatory β-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia
- Pham Bich Ngoc;
- Thanh Binh Pham;
- Hai Dang Nguyen;
- Thu Trang Tran;
- Hoang Ha Chu;
- ... Lee, Jeong-Hyung;
- 외 2명
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31초록
One new beta-carboline alkaloid 7-methoxy-(9H-beta-carbolin-1-il)-(E)-1-propenoic acid (1) together with 9-methoxycanthin-6-one (2) and 9-hydroxycanthin-6-one (3) were isolated from the hairy-root cultures of Eurycoma longifolia. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were investigated. Compound 1 strongly inhibited the production of NO while 2 and 3 having weak or inactive effect. Consistently, compound 1 decreased the expression of cyclooxygenase-2 and inducible nitric oxide synthase.
키워드
Eurycoma longifolia; hairy-root cultures; beta-carboline alkaloid; CONSTITUENTS
- 제목
- A new anti-inflammatory β-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia
- 저자
- Pham Bich Ngoc; Thanh Binh Pham; Hai Dang Nguyen; Thu Trang Tran; Hoang Ha Chu; Van Minh Chau; Lee, Jeong-Hyung; Tien Dat Nguyen
- 발행일
- 2016
- 유형
- Article
- 권
- 30
- 호
- 12
- 페이지
- 1360 ~ 1365
- 언어
- ENG
- 출판사
- TAYLOR & FRANCIS LTD
- 발행국가
- 영국
- 분량
- 6 페이지
- ISSN
- E 1478-6427
P 1478-6419