건강보험 청구자료를 활용한 최근 10년 간의 국내 항우울제 처방 양상 연구

초록

The aim of this study was to investigate the prescribing patterns of antidepressants in South Korea using the National Health Insurance Service claims data. Methods: All antidepressants prescribed in South Korea between 2014 and 2023 (including selective serotonin reuptake inhibitor [SSRI], serotonin-norepinephrine reuptake inhibitor [SNRI], tricyclic antidepressant [TCA], monoamine oxidase inhibitor [MAOI], and others) were used in this study. The study population consisted of patients with at least one antidepressant prescription between January 1, 2014, and December 31, 2023. The prescribing patterns of antidepressants were examined by age, sex, antidepressant class, and indications across time periods. A timeseries analysis with autoregressive model was applied to assess trends in prescribing patterns over time. Results: This study showed that the number of patients prescribed antidepressants (estimate [p-value]: 267,365 [< 0.0001]) and the number of prescriptions has been increasing (1,949,634 [< 0.0001]). The prescribing proportion of SSRIs steadily increased, while that of TCAs continuously declined. The proportion across sex showed no significant changes over time. In patients aged 15–18 years, the proportion of antidepressant prescriptions increased from 1.3% in 2014–2016 to 1.9% in 2021–2023. Depressive episodes accounted for the highest prescribing proportion. Antidepressant prescriptions for dementia in Alzheimer’s disease increased steadily over the time periods, from 2.76% to 4.45% and then to 5.98%. Conclusion: This study showed the increasing trend of overall antidepressant prescriptions and showed variations in prescribing patterns based on antidepressant classes, indications, years, and age groups. These findings provide foundational data for establishing policies to use antidepressants safely

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