Selective functionalization of methylene bridges of calix[6]arenes. Isolation and identification of stable conformers of methyl ether of p-tert-butylcalix[6]arene

초록

Direct disubstitution at the methylene bridges of p-tert-butylcalix[6] arenemethyl ether has been achieved for the first time using a lithiation-substitution protocol. Two stable conformers have been isolated using column chromatography, and their structures have been unambiguously confirmed from 1D, 2D and variable temperature NMR studies and single crystal X-ray structure analysis.

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