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Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin
- Choi, Sae Rom;
- Jang, Dong-Jin;
- Kim, Sanghyun;
- An, Sunhyung;
- Lee, Jinwoo;
- 외 2명
Citations
WEB OF SCIENCE
29Citations
SCOPUS
32초록
We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this systembehaves under different pH conditions.
키워드
DRUG-DELIVERY; ORAL DELIVERY; IN-VITRO; NANOPARTICLES; RELEASE; CHALLENGES; STABILITY; MATRICES; SYSTEMS; PROTEIN
- 제목
- Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin
- 저자
- Choi, Sae Rom; Jang, Dong-Jin; Kim, Sanghyun; An, Sunhyung; Lee, Jinwoo; Oh, Euichaul; Kim, Jungbae
- 발행일
- 2014
- 유형
- Article
- 권
- 2
- 호
- 6
- 페이지
- 616 ~ 619