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Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity
- Hung, Tran Manh;
- Cao Van Thu;
- Nguyen Tien Dat;
- Ryoo, Sung-Woo;
- Lee, Jeong Hyung;
- 외 5명
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62초록
Three new homoiso. avonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma. (C) 2010 Elsevier Ltd. All rights reserved.
키워드
Ophiopogon japonicus; Liliaceae; Homoisoflavonoids; Anti-inflammatory; CONSTITUENTS; EOTAXIN; TUBER; EOSINOPHIL; GLYCOSIDES; CELLS; RECRUITMENT; EXPRESSION; EXTRACT
- 제목
- Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity
- 저자
- Hung, Tran Manh; Cao Van Thu; Nguyen Tien Dat; Ryoo, Sung-Woo; Lee, Jeong Hyung; Kim, Jin Cheol; Na, Minkyun; Jung, Hyun-Ju; Bae, KiHwan; Min, Byung Sun
- 발행일
- 2010-04-15
- 유형
- Article
- 권
- 20
- 호
- 8
- 페이지
- 2412 ~ 2416
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 5 페이지
- ISSN
- E 1464-3405
P 0960-894X