Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

Wang, Siwen; Casey, Emma; Sordillo, Joanne; Aguilar-Lacasana, Sofia; Berstein, Fernanda Morales; Biedrzycki, Richard J.; Brescianini, Sonia; Chen, Su; Hough, Amy; Isaevska, Elena; Kim, Woo Jin; Lecorguille, Marion; Li, Sebastian Shaobo; Page, Christian M.; Park, Jaehyun; Roeder, Stefan; Salontaji, Kristina; Santorelli, Gillian; Sun, Yidan; Won, Sungho; Zillich, Eric; Zillich, Lea; Annesi-Maesano, Isabella; Arshad, S. Hasan; Bustamante, Mariona; Cecil, Charlotte A. M.; Elliott, Hannah R.; Ewart, Susan; Felix, Janine F.; Gagliardi, Luigi; Haberg, Siri E.; Herberth, Gunda; Heude, Barbara; Holloway, John W.; Huels, Anke; Karmaus, Wilfried; Koppelman, Gerard H.; London, Stephanie J.; Mumford, Sunni L.; Nistico, Lorenza; Popovic, Maja; Rusconi, Franca; Schisterman, Enrique F.; Stein, Dan J.; Send, Tabea; Tiemeier, Henning; Vonk, Judith M.; Vrijheid, Martine; Wiemels, Joseph Leo; Witt, Stephanie H.; Wright, John; Yeung, Edwina H.; Zar, Heather J.; Zenclussen, Ana C.; Zhang, Hongmei; Chavarro, Jorge E.; Hivert, Marie-France

doi:10.1126/sciadv.adr2084

상세 보기

Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

Wang, Siwen;
Casey, Emma;
Sordillo, Joanne;
Aguilar-Lacasana, Sofia;
Berstein, Fernanda Morales;
... Kim, Woo Jin;
외 51명

Citations

WEB OF SCIENCE

4

Citations

SCOPUS

4

초록

Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%, P < 1.0 x 10(-7)): MAP2K2 (cg19423175), LIM2 (cg01500140), CNP (cg13917614), BLM (cg18247172), RASA3 (cg22348356), and RUNX3 (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery's molecular influence on offspring health.

키워드

COHORT PROFILE; NORWEGIAN MOTHER; QUALITY-CONTROL; NORMALIZATION; DETERMINANTS; ASSOCIATION; RESOURCE; NEWBORNS; OUTCOMES; SMOKING

제목: Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

저자: Wang, Siwen; Casey, Emma; Sordillo, Joanne; Aguilar-Lacasana, Sofia; Berstein, Fernanda Morales; Biedrzycki, Richard J.; Brescianini, Sonia; Chen, Su; Hough, Amy; Isaevska, Elena; Kim, Woo Jin; Lecorguille, Marion; Li, Sebastian Shaobo; Page, Christian M.; Park, Jaehyun; Roeder, Stefan; Salontaji, Kristina; Santorelli, Gillian; Sun, Yidan; Won, Sungho; Zillich, Eric; Zillich, Lea; Annesi-Maesano, Isabella; Arshad, S. Hasan; Bustamante, Mariona; Cecil, Charlotte A. M.; Elliott, Hannah R.; Ewart, Susan; Felix, Janine F.; Gagliardi, Luigi; Haberg, Siri E.; Herberth, Gunda; Heude, Barbara; Holloway, John W.; Huels, Anke; Karmaus, Wilfried; Koppelman, Gerard H.; London, Stephanie J.; Mumford, Sunni L.; Nistico, Lorenza; Popovic, Maja; Rusconi, Franca; Schisterman, Enrique F.; Stein, Dan J.; Send, Tabea; Tiemeier, Henning; Vonk, Judith M.; Vrijheid, Martine; Wiemels, Joseph Leo; Witt, Stephanie H.; Wright, John; Yeung, Edwina H.; Zar, Heather J.; Zenclussen, Ana C.; Zhang, Hongmei; Chavarro, Jorge E.; Hivert, Marie-France

DOI: 10.1126/sciadv.adr2084

발행일: 2024-11-27

유형: Article

저널명: Science Advances

권: 10

호: 48