In vitro small intestinal absorption and pH stability of tableted KIOM-C and KIOM-MA-128

초록

Hot water extracts, KIOM-C and KIOM-MA-128, were formulated into tablets and three kinds of absorption enhancers were included in the tablets. The mixture of starch and lactose was used as an excipient, sodium carboxymethylcellulose as a disintegrating agent, and magnesium stearate as a binder. The weight ratio of water extract/excipient/disintegrating agent/absorption enhancer/binder was 80/7/10/2/1. The tablets were completely disintegrated in an aqueous solution in 40 min, and the disintegration rates were almost the same with all the tablets tested. Among the enhancers, EDTA was the most effective in enhancing the in vitro small intestine absorption of KIOM-C and KIOM-MA-128.

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