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초록
Phosphoryl alkylindium reagents are generated in situ from the direct insertion of indium with bromoalkyl phosphonates in the presence of CuCl, and their synthetic application to arylalkyl phosphonates is reported via a Pd-catalyzed cross-coupling reaction with tolerance of a diversity of functional groups including ester, ketone, aldehyde, nitrile, nitro, trifluoromethyl, chloride, methoxy, hydroxy, and amino.
키워드
PHOSPHORORGANISCHE VERBINDUNGEN; ACID ANTIBIOTICS; ARYL HALIDES; ONE-POT; REAGENTS; INDIUM; CYCLIZATION; VINYL; DERIVATIVES; INHIBITORS
- 제목
- In Situ Generation of Phosphoryl Alkylindiums and Their Synthetic Application to Arylalkyl Phosphonates via Palladium-Catalyzed Cross-Coupling Reactions
- 저자
- Kim, Sanghyuck; Kim, Cheol-Eui; Seo, Boram; Lee, Phil Ho
- 발행일
- 2014-11-07
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 16
- 호
- 21
- 페이지
- 5552 ~ 5555