Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

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초록

Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug's shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector.

키워드

RESIDUAL SOLVENTSTHERMODYNAMIC PROPERTIESORGANIC-SOLVENTSCHOLINE CHLORIDESOLUBLE DRUGSIN-VITROWATERSYSTEMSSTRATEGIESBEHAVIOR
제목
Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery
저자
Sharma, AnshuPark, Yea RockGarg, AmanLee, Bong-Seop
DOI
10.1021/acs.jmedchem.4c01550
발행일
2024-08-26
유형
Article
저널명
Journal of Medicinal Chemistry
67
17
페이지
14807 ~ 14819