피부 부착성 향상을 위한 MPD/Pullulan 기반 나노전달체의 제조 및 화장품 적용 특성

초록

As the population ages, the management of skin odor in older adults is becoming increasingly important in the cosmetic field, and delivery technologies are required to retain age-related odor care ingredients on the skin for longer periods. In this study, skin-adhesive nanocarriers were prepared using a lipid composition of ceramide NP, cholesterol, and hydrogenated lecithin, with methylpropanediol (MPD) and polymers that may improve adhesion, and their applicability to cosmetic formulations was evaluated. The MPD#2 formulation containing 0.3% pullulan maintained a particle size of 131.5 nm and a stable appearance after 4 weeks, and spherical nanostructures were observed by cryogenic transmission electron microscopy (Cryo-TEM). In the artificial membrane washing test, MPD#2 showed higher retention than MPD#3 and the lowest fluorescence signal in the wash solution, indicating superior washing resistance. In the primary irritation test, the formulations were also classified in the low-irritation category. These results suggest that MPD/Pullulan-based nanocarriers can be used as a delivery platform to improve skin adhesion and persistence in cosmetics for older adults.

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