Two New Pterocarpans from Lespedeza tomentosa

초록

A phytochemical study on the MeOH extract of Lespedeza tomentosa roots led to the discovery of two new pterocarpans (labelled tomentocarpan A and B), along with three known pterocarpans and a flavanone. The structures of the two new compounds were found to be (6aR,11aR)-1-methoxy-8-hydroxy-2 ',2 '-dimethylpyrano[5 ',6 ':2,3]-2 '',2 ''-dimethylpyrano[6 '',5 '':9,10]pterocarpan (5), and 1-methoxy-8-hydroxy-2 ',2 '-dimethylpyrano[5 ',6 ':2,3]-2 '',2 ''-dimethylpyrano[6 '',5 '':9,10]pterocarp-6a(11a)-ene (6), based on comprehensive spectral and physical property analyses. Compounds 5 and 6 showed butyrylcholinesterase inhibitory activities with IC50 values of 0.50 and 0.62 mM, respectively.

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