Gold nanoparticles-loaded cinnamoyl pluronic F-127/cinnamoyl alginate microparticles prepared by a spray-drying method

초록

A gold nanoparticle (GNP)-loaded microparticle was prepared by spray drying the mixture solution of GNP, cinnamoyl pluronic F127, and cinnamoyl alginate, and by dimerizing the cinnamoyl groups under the irradiation of UV light. The cinnamic acid content in the cinnamoyl polymers was determined by H-1 NMR spectroscopy and colorimetric method. The GNP content in the surface of microparticle was 6.45% (w/w), determined by energy-dispersive X-ray spectroscopy. The cumulative release amount for 12h at 45 degrees C was markedly higher than that observed at lower temperatures. Near-infrared irradiation significantly promoted the release from the GNP-loaded microparticle because of heat generation from GNP.

키워드