Antioxidant and Antidiabetic Activities of Eucommia ulmoides Bark

초록

Eucommia ulmoides bark extracts by cold water, boiling water, 100% EtOH, 70% EtOH, 100% MeOH, 70% MeOH and CHCl 3 were assayed for their medicinal effects. The antioxidant activity of the extracts ranged from IC 50 125.2 to IC 50 872.7 µ g/m l in the 1,1-diphenyl-2-picrylhydrazyl (DDPH) free radical-scavenging assay, and cold water extracts had the highest antioxidant activity. CHCl 3 extracts had the highest inhibitory effect on angiotensin I-converting enzyme ( A C E ) g i v i n g i n h i b i t i o n o f u p t o 5 6 . 4 % a t a c o n c e n t r a t i o n o f 1 m g / m l . Extracts in 100% EtOH had the greatest inhibitory effect on á-amylase activity (IC 50 = 1 7 4 . 6 µ g/m l ), and 70% MeOH extracts had the greatest inhibitory effect on α -glucosidase activity (IC 50 = 1 4 . 0 µ g/m l ). Taken together, these results provided the in vitro evidence on the ACE, amylase and glucosidase inhibitory actions of E. ulmoides bark that form the pharmacological basis for its antihypertensive and antidiabetic action

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