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Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil
- Lee, Ji Hyun;
- Park, Han Na;
- Park, Hyoung Joon;
- Kim, Nam Sook;
- Park, Sung-Kwan;
- ... Lee, Jongkook;
- 외 1명
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2초록
A new minoxidil analogue was detected in an illegal dietary supplement advertised as a hair-growth treatment. The analogue was identified using ultra-performance liquid chromatography (UPLC), high-resolution mass spectrometry (LC-HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was structurally elucidated as a minoxidil analogue in which the piperidinyl group of minoxidil was replaced with a pyrrolidinyl group corresponding to a molecular formula of C8H13N5O. The new analogue has been named triaminodil. As this is the first report of the compound, there are no chemical, toxicology or pharmacological data available.
키워드
Hair growth; dietary supplement; minoxidil analogue; triaminodil; LC-HR-MS; NMR; PATTERN HAIR LOSS; ANDROGENETIC ALOPECIA; TOPICAL MINOXIDIL; HUMAN PLASMA; FINASTERIDE; WOMEN; MS/MS
- 제목
- Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil
- 저자
- Lee, Ji Hyun; Park, Han Na; Park, Hyoung Joon; Kim, Nam Sook; Park, Sung-Kwan; Lee, Jongkook; Baek, Sun Young
- 발행일
- 2018
- 유형
- Article
- 저널명
- Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
- 권
- 35
- 호
- 1
- 페이지
- 2 ~ 9