Neuroprotective Activity of Clematis mandshurica; [위령선 추출물의 신경세포 보호 활성]

초록

Oxidative stress is widely recognized as a central driver in the progression of neurodegenerative diseases, where it contributes to neuronal apoptosis through diverse intracellular signaling mechanisms. In this study, we examined the neuroprotective potential of Clematis mandshurica, a traditional Korean medicinal herb historically used to alleviate conditions such as urethritis, carbuncles, and certain malignancies. To model oxidative injury, neuronal cells were exposed to excessive glutamate, a treatment known to elevate reactive oxygen species (ROS), trigger intracellular calcium (Ca2+) overload, impair mitochondrial membrane potential, and diminish the activities of key glutathione-dependent enzymes, including glutathione reductase (GR) and glutathione peroxidase (GPx). Treatment with C. mandshurica extract effectively counteracted these glutamate-induced alterations, as demonstrated by improved cell viability in MTT assays, suppression of ROS and Ca2+ accumulation, preservation of mitochondrial function, and restoration of GR and GPx activity. Collectively, these findings suggest that C. mandshurica exerts robust cytoprotective actions and holds promise as a potential therapeutic agent for neurodegenerative disorders characterized by oxidative stress, including Alzheimer’s disease. © 2026, Korean Society of Pharmacognosy. All rights reserved.

키워드