Tosyl Hydrazine-Promoted Tandem Condensation and Cyclization of Acyl Azobenzenes Enabling Access to 2H-Indazoles under Metal-Free Aerobic Conditions

초록

Tosyl hydrazine-promoted tandem condensation and cyclization of 2-acyl azobenzenes under metal-free aerobic conditions was demonstrated to give 2-aryl-2H-indazoles having alkyl- or aryl groups at the 3-position in quantitative yields through the release of water, molecular nitrogen, and sulfinic acid. All of the examples produced the corresponding 2H-indazoles in quantitative yields. The present reaction was determined to have a wide substrate scope and good functional group tolerance.

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