Bone union rate following instrumented posterolateral lumbar fusion: Comparison between demineralized bone matrix versus hydroxyapatite

초록

Study Design: Retrospective study. Purpose: To compare the union rate of posterolateral lumbar fusion (PLF) using demineralized bone matrix (DBM) versus hydroxyapatite (HA) as bone graft extender. Overview of Literature: To our knowledge, there has been no clinical trial to compare the outcomes of DBM versus HA as a graft material for PLF. Methods: We analyzed prospectively collected data from consecutive 79 patients who underwent instrumented PLF. Patients who received DBM were assigned to group B (n=38), and patients who received HA were assigned into group C (n=41). The primary study outcome was fusion rate assessed with radiographs. The secondary outcomes included pain intensity using a visual analogue scale, functional outcome using Oswestry disability index score, laboratory tests of inflammatory profiles and infection rate. Results: One year postoperatively, bone fusion was achieved in 73% in group B and 58% in group C without significant difference between the groups (p =0.15). There were no differences between the groups with respect to secondary outcomes. Conclusions: DBM would provide noninferior outcomes compared to the HA as a fusion material for PLF, and could be a notable alternative. © 2016 by Korean Society of Spine Surgery.

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