TC1(C8orf4) is upregulated by 1L-1β/TNF-α and enhances proliferation of human follicular dendritic cells

Kim, Youngmi; Kim, Jungtae; Park, Juhee; Bang, Seunghyun; Jung, Yusun; Choe, Jongseon; Song, Kyuyoung; Lee, Inchul

doi:10.1016/j.febslet.2006.05.036

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TC1(C8orf4) is upregulated by 1L-1β/TNF-α and enhances proliferation of human follicular dendritic cells

Kim, Youngmi;
Kim, Jungtae;
Park, Juhee;
Bang, Seunghyun;
Jung, Yusun;
... Choe, Jongseon;
외 2명

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초록

Follicular dendritic cells (FDC) play crucial roles in immune regulation. TNF-alpha has been shown to be essential to the FDC network. However, the molecular regulation of FDC proliferation has not been characterized. Here, we show that TC1(C8orf4), a novel positive regulator of the Wnt/beta-catenin pathway in vertebrates, is upregulated by IL-1 beta and TNF-alpha in the human FDC-like line HK. TC1 enhances HK cell proliferation, while TC1-knockdown inhibits the proliferation induced by IL-1 beta, suggesting a role of TO as a regulator of FDC proliferation. The regulation by pro-inflammatory cytokines suggests that TO might be implicated in linking local inflammation to immune response by stimulating FDC. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

키워드

TC1(C8orf4); NF-kB; IL-1 beta; TNF-alpha; Wnt/beta-catenin pathway; HK cell; NF-KAPPA-B; BETA-CATENIN; TNF-ALPHA; ACTIVATION; EXPRESSION; CANCER; C8ORF4; TC-1; WNT

제목: TC1(C8orf4) is upregulated by 1L-1β/TNF-α and enhances proliferation of human follicular dendritic cells

저자: Kim, Youngmi; Kim, Jungtae; Park, Juhee; Bang, Seunghyun; Jung, Yusun; Choe, Jongseon; Song, Kyuyoung; Lee, Inchul

DOI: 10.1016/j.febslet.2006.05.036

발행일: 2006-06-12

유형: Article

저널명: FEBS Letters

권: 580

호: 14

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