상세 보기
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells
- An, Ji-Young;
- Lee, Hwi-Ho;
- Shin, Ji-Sun;
- Yoo, Hyung-Seok;
- Park, Jong Seon;
- ... Son, Seung Hwan;
- 외 5명
Citations
WEB OF SCIENCE
17Citations
SCOPUS
17초록
In an effort to identify novel anti-inflammatory compounds, a series of flavone derivatives were synthesized and biologically evaluated for their inhibitory effects on the production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)), representative pro-inflammatory mediators, in LPS-induced RAW 264.7 cells. Their structure-activity relationship was also investigated. In particular, we found that compound 3g displayed more potent inhibitory activities on PGE2 production, similar inhibitory activities on NO production and less weak cytotoxicity than luteolin, a natural flavone known as a potent anti-inflammatory agent. (C) 2017 Elsevier Ltd. All rights reserved.
키워드
Flavone; Nitric oxide (NO); Prostaglandin E-2 (PGE(2)); Anti-inflammatory; RAW 264.7 cell; COX-2 ACTIVITY; INFLAMMATION; CANCER; POLYPHENOLS; ANTICANCER; PATHWAY; CHRYSIN; ACID; INOS; NO
- 제목
- Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells
- 저자
- An, Ji-Young; Lee, Hwi-Ho; Shin, Ji-Sun; Yoo, Hyung-Seok; Park, Jong Seon; Son, Seung Hwan; Kim, Sang Won; Yu, Jihyun; Lee, Jun; Lee, Kyung-Tae; Kim, Nam-Jung
- 발행일
- 2017-06-01
- 유형
- Article
- 권
- 27
- 호
- 11
- 페이지
- 2613 ~ 2616