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초록
A rhodium-catalyzed cyclization reaction of sulfoximines with 3-diazoindolin-2-imines is described. This protocol provides a wide range of indolo-1,2-benzothiazines in moderate to excellent yields together with the release of molecular nitrogen and p-toluenesulfonamide. The present method involves the N-H/C-H activation of S-aryl sulfoximines and has the advantages of a broad substrate scope.
키워드
benzothiazine; catalysis; C-H activation; rhodium; sulfoximine; N-ALKYNYLATED SULFOXIMINES; C-H ACTIVATION/CYCLIZATION; BOND FORMATION; CARBENOID FUNCTIONALIZATION; SULFONYL AZIDES; DIAZO-COMPOUNDS; DIRECTING GROUP; CHIRAL SULFUR; RING-SYSTEMS; ONE-POT
- 제목
- Synthesis of Indolo-1,2-Benzothiazines from Sulfoximines and 3-Diazoindolin-2-imines
- 저자
- Ko, Gi Hoon; Son, Jeong-Yu; Kim, Hyunseok; Maeng, Chanyoung; Baek, Yonghyeon; Seo, Boram; Um, Kyusik; Lee, Phil Ho
- 발행일
- 2017-10-04
- 유형
- Article
- 권
- 359
- 호
- 19
- 페이지
- 3362 ~ 3370