Comparison of Everolimus- and Sirolimus-Eluting Stents in Patients With Long Coronary Artery Lesions A Randomized LONG-DES-III (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III) Trial

초록

Objectives This study compared everolimus-eluting stents (EES) and sirolimus-eluting stents (SES) for long coronary lesions. Background Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. Methods This randomized, multicenter, prospective trial compared the use of long EES with SES in 450 patients with long (>= 25 mm) native coronary lesions. The primary endpoint of the trial was insegment late luminal loss at 9-month angiographic follow-up. Results The EES and SES groups had similar baseline characteristics. Lesion length was 34.0 +/- 15.4 mm in the EES group and 34.3 +/- 13.5 mm in the SES group (p = 0.85). Nine-month angiographic follow-up was performed in 80% of the EES group and 81% of the SES group (p = 0.69). In-segment late loss as the primary study endpoint was significantly larger in the EES group than in the SES group (0.17 +/- 0.41 mm vs. 0.09 +/- 0.30 mm, p for noninferiority = 0.96, p for superiority = 0.04). The in-segment binary restenosis rate was also higher in the EES group than in the SES group (7.3% vs. 2.7%, p = 0.046). However, in-stent late loss (0.22 +/- 0.43 mm vs. 0.18 +/- 0.28 mm, p = 0.29) and in-stent binary restenosis rate (3.9% vs. 2.7%, p = 0.53) were similar among the 2 groups. The incidence of any clinical outcomes (death, myocardial infarction, stent thrombosis, target lesion revascularization, and composite outcomes) was not statistically different between the 2 groups. Conclusions For patients with long native coronary artery disease, EES implantation was associated with greater angiographic in-segment late loss and higher rates of in-segment restenosis compared with SES implantation. However, clinical outcomes were both excellent and not statistically different (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III [LONG-DES-III]; NCT01078038) (J Am Coll Cardiol Intv 2011;4:1096-103) (C) 2011 by the American College of Cardiology Foundation

키워드