Triterpenoidal saponins of Pulsatilla koreana roots

초록

Sixteen (1-16) triterpenoidal saponins were isolated from the roots of Pulsatilla koreana, of which four were determined as the previously unknown 23-hydroxy-3 beta-[(O-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl ester (1), 23-hydroxy-3 beta-[(O-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl ester (2), 3 beta-[O-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (3), and 3 beta-[(O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-[beta-D-glucopyranosyl-(1 -> 4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (4), respectively, based on spectroscopic analysis. The inhibition of the lipopolysaccharide-induced nitric oxide production of sixteen isolated compounds was evaluated in RAW 264.7 cells at concentrations ranging from 1 mu M to 100 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

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