Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines

Che, Haiyan; Fang, Yuanying; Gurung, Santosh K.; Luo, Jun; Yoon, Deok Hyo; Sung, Gi-Ho; Kim, Tae Woong; Park, Haeil

doi:10.5012/bkcs.2014.35.7.2038

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Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines

Che, Haiyan;
Fang, Yuanying;
Gurung, Santosh K.;
Luo, Jun;
Yoon, Deok Hyo;
외 3명

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3

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SCOPUS

3

초록

4-(tert-Octyl)phenol derivative bearing, the D-mannitol substructure (6a, 6b, 7) were prepared from D-mannitol and evaluated their anticancer activity against human lung (A549) and prostate (Lncap, Du145, PC3) cancer cell lines. Among derivatives tested, the bis(tert-octyl)phenoxy compound 7 exhibited strongest proliferation inhibitory activities against human cancer cell lines tested, especially high sensitivity to human Du145 prostate cancer cells (IC50 = 7.3 mu M).

키워드

Cordyceps militaris; Militarin; 4-(tert-Octyl)phenol derivatives; D-Mannitol substructure; Anticancer activity; CORDYCEPS-MILITARIS; 3'-DEOXYADENOSINE

제목: Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines

저자: Che, Haiyan; Fang, Yuanying; Gurung, Santosh K.; Luo, Jun; Yoon, Deok Hyo; Sung, Gi-Ho; Kim, Tae Woong; Park, Haeil

DOI: 10.5012/bkcs.2014.35.7.2038

발행일: 2014-07-20

유형: Article

저널명: Bulletin of the Korean Chemical Society

권: 35

호: 7

페이지: 2038 ~ 2042