Inhibitory effect of synthetic C-C biflavones on various phospholipase A2s activity

Moon, Tae Chul; Quan, Zhej'iu; Kim, Jeongsoo; Kim, Hyun Pyo; Kudo, Ichiro; Murakami, Makodo; Park, Haeil; Chang, Hyeun Wook

doi:10.1016/j.bmc.2007.07.054

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Inhibitory effect of synthetic C-C biflavones on various phospholipase A2s activity

Moon, Tae Chul;
Quan, Zhej'iu;
Kim, Jeongsoo;
Kim, Hyun Pyo;
Kudo, Ichiro;
외 3명

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초록

Several prototypes of C-C biflavones (a-f) were synthesized and evaluated their inhibitory activity against phospholipase A(2)s (PLA(2)s) activity. The synthetic C-C biflavones (a-f) showed rather different inhibitory activity against various PLA(2)s. Most synthetic C-C biflavonoids exhibited potent and broad inhibitory activity against various sPLA(2)s and cPLA(2) tested regardless of their structural array. In particular, of natural and synthetic biflavonoids tested, the synthetic C-C biflavonoid (d) only showed inhibitory activity against sPLA, X. None of the natural and synthetic biflavonoids tested showed inhibitory activity against sPLA, IB. Further chemical l modification of these basic structures will be carried out in order to investigate the synthetic C C biflavones which possess more selective inhibitory activity against isozymes of PLA(2) (C) 2007 Published by Elsevier Ltd.

키워드

synthetic C-C biflavones; suzuki C-C cross-coupling reaction; phospholipase A(2)(PLA(2)) isozymes; inflammation; ARACHIDONIC-ACID RELEASE; CROHNS-DISEASE; A(2); FLAVONOIDS; GINKGETIN; BIOLOGY; RAT; IIA

제목: Inhibitory effect of synthetic C-C biflavones on various phospholipase A2s activity

저자: Moon, Tae Chul; Quan, Zhej'iu; Kim, Jeongsoo; Kim, Hyun Pyo; Kudo, Ichiro; Murakami, Makodo; Park, Haeil; Chang, Hyeun Wook

DOI: 10.1016/j.bmc.2007.07.054

발행일: 2007-11

유형: Article

저널명: Bioorganic & Medicinal Chemistry

권: 15

호: 22

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