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PODOPLANIN-TARGETABLE MR/OPTIC DUAL-MODE NANOCOMPOSITES FOR GLIOBLASTOMA MULTIFORME IN MOUSE BRAIN CANCER
- Lee, H.;
- Cho, E. J.;
- Son, H.;
- Kim, H. O.;
- Hong, Y.;
- 외 7명
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0초록
It is very desirable to design dual-mode nanocomposites for diagnostic applications via flexible strategies. Herein, we proposed to synthesize one type of multifunctional magnetic resonance (MR)/optic nanocomposites based on manganese ferrite magnetic nanoparticles (MFNPs) modified by fluorescent podoplanin (PDPN) antibodies. MFNPs were synthesized using a thermal decomposition method and were modified by the fluorescent PDPN antibodies on their surfaces. The fluorescent PDPN antibody-conjugated MFNPs enabled strong MR imaging and fluorescence imaging due to the antibodies that targeted brain tumors. These results demonstrate that MR/optic nanocomposites have potential as precision diagnostic systems for brain cancer.
키워드
MRI; Optical imaging; Brain cancer; Glioblastoma multiforme; Podoplanin; GSC11; MR; NANOPARTICLES; CELLS
- 제목
- PODOPLANIN-TARGETABLE MR/OPTIC DUAL-MODE NANOCOMPOSITES FOR GLIOBLASTOMA MULTIFORME IN MOUSE BRAIN CANCER
- 저자
- Lee, H.; Cho, E. J.; Son, H.; Kim, H. O.; Hong, Y.; Yang, S. H.; Yoon, S. J.; Lee, J. H.; Shim, J. K.; Chang, J. H.; Kang, S. G.; Huh, Y. M.
- 발행일
- 2020-07
- 유형
- Article
- 권
- 15
- 호
- 3
- 페이지
- 841 ~ 847
- 언어
- ENG
- 출판사
- VIRTUAL CO PHYSICS SRL
- 발행국가
- 루마니아
- 분량
- 7 페이지
- ISSN
- P 1842-3582