Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

Lee, Jongkook; Han, Sun-Young; Jung, Heejung; Yang, Jeon; Choi, Jie-Won; Chae, Chong Hack; Park, Chi Hoon; Choi, Sang Un; Lee, Kwangho; Du Ha, Jae; Lee, Chong Ock; Ryu, Jae Wook; Kim, Hyoung Rae; Koh, Jong Sung; Cho, Sung Yun

doi:10.1016/j.bmcl.2012.04.083

상세 보기

Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

Lee, Jongkook;
Han, Sun-Young;
Jung, Heejung;
Yang, Jeon;
Choi, Jie-Won;
외 10명

Citations

WEB OF SCIENCE

23

Citations

SCOPUS

24

초록

A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety. (C) 2012 Elsevier Ltd. All rights reserved.

키워드

Cancer; c-Met kinase; Aminopyridine; Benzoxazole; SIGNALING PATHWAY; ACQUIRED-RESISTANCE; CANCER; TARGET

제목: Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

저자: Lee, Jongkook; Han, Sun-Young; Jung, Heejung; Yang, Jeon; Choi, Jie-Won; Chae, Chong Hack; Park, Chi Hoon; Choi, Sang Un; Lee, Kwangho; Du Ha, Jae; Lee, Chong Ock; Ryu, Jae Wook; Kim, Hyoung Rae; Koh, Jong Sung; Cho, Sung Yun

DOI: 10.1016/j.bmcl.2012.04.083

발행일: 2012-06-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 22

호: 12

페이지: 4044 ~ 4048

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 5 페이지

ISSN: E 1464-3405
P 0960-894X