Application of plasma jet to the inhibition of the proliferation of hepatic malignant cells via reactive oxygen species generation

초록

In vitro treatment of hepatic malignant cells with plasma-activated medium conjugated with gemcitabine was investigated with a He plasma jet generated by a two-ring dielectric barrier discharge (DBD) reactor. The DBD reactor was operated by high-voltage pulses of alternating polarity (frequency: 20 kHz; pulse width: 4 mu s). The electron density of plasma plume was estimated to be 9x10(12) to 10x10(12) cm(-3), and the jet temperature was around 36celcius. The plasma jet exhibited the inhibitory effects on the growth of hepatic malignant cells via the generation of reactive oxygen species, which could be potentially applicative in anticancer therapies. The optimization of the operating parameters and configuration of the plasma jet would help increase the possibility in practical cancer treatments.

키워드