Lack of association between apolipoprotein p polymorphism and vascular dementia in Koreans

초록

To investigate an association of vascular dementia (VD) with the apolipoprotein E (APOE) polymorphism, the APOE polymorphism of 100 VD patients, 100 age- and gender-matched Alzheimer disease (AD) patients, and 200 age- and gender-matched nondemented control (NC) subjects was genotyped. The distribution of APOE polymorphism was compared. Neither the APOE epsilon 4 allele nor the APOE epsilon 2 allele was more prevalent in the VD patients compared with the NC subjects (P > .1 by the chi(2) test), which was the case when both men and women were analyzed separately (P > .1 by the chi(2) test) and when young patients (75 years old or less) and old patients (more than 75 years old) were analyzed separately (P > .1 by the chi(2) test). The estimated statistical power was over 0.80 when the odds ratios (OR) for VD conferred to the APOE epsilon 4 are assumed to be higher than 2.2 and the type I error probability is set at 0.05, which is much higher than the power of the previous studies on the VD/APOE association. In conclusion, the results suggested that APOE epsilon 4 allele does not confer the risk for VD, and even if it does, it does so very modestly.

키워드