Protective effect of Angelica keiskei juice and Oenanthe javanica DC juice on oxidative stress

초록

The objectives of the present study were to investigate the protective effects of Angelica keiskei juice and Oenanthe javanica juice against oxidative damage in LLC-PK<inf>1</inf> renal epithelial cells and to evaluate their free radicalscavenging activities. Both A. keiskei juice and O. javanica juice showed a strong in vitro antioxidant activities such as α, α-diphenyl-β-picrylhydrazyl (DPPH), nitric oxide (NO), O2., and ·OH radical-scavenging activities. The LLC-PK<inf>1</inf> cells showed significant lipid peroxidation and cell death due to oxidative stress when it was induced by 2, 2'-azobis (2-amidinopropane) dihydrochloride (AAPH), sodium nitroprusside (SNP), pyrogallol, and 3-morpholinosydnonimine (SIN-1). Treatment with both A. keiskei juice and O. javanica juice significantly increased cell viability and inhibited lipid peroxidation. These results suggest that A. keiskei juice and O. javanica juice are potential natural antioxidants. © The Korean Society of Food Science and Technology.

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