Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

Kang, Tae-cheon; Park, Seung-kook; Hwang, In Koo; An, Sung-jin; Hoon Bahn, Jae; Won Kim, Dae; Young Choi, Soo; Kwon, Ohshin; Baek, Nam In; Yong Lee, Hyeon; Ho Won, Moo

doi:10.1016/S0006-8993(02)03566-7

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Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

Kang, Tae-cheon;
Park, Seung-kook;
Hwang, In Koo;
An, Sung-jin;
Hoon Bahn, Jae;
외 6명

Citations

SCOPUS

16

초록

To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons. © 2002 Elsevier Science B.V. All rights reserved.

키워드

Epileptogenesis; Gerbil; Hippocampus; Pyridoxal 5′-phosphate; Pyridoxal kinase; Seizure

제목: Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

저자: Kang, Tae-cheon; Park, Seung-kook; Hwang, In Koo; An, Sung-jin; Hoon Bahn, Jae; Won Kim, Dae; Young Choi, Soo; Kwon, Ohshin; Baek, Nam In; Yong Lee, Hyeon; Ho Won, Moo

DOI: 10.1016/S0006-8993(02)03566-7

발행일: 2002

유형: Article

저널명: Brain Research

권: 957

호: 2

페이지: 242 ~ 250