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Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
- Kang, Sungkyoung;
- Lee, Wonchul;
- Jung, Byunghyuck;
- Lee, Hee-Seung;
- Kang, Sung Ho
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5초록
An efficient synthetic route to the C1-C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn-aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti-aldol reaction for C3 and C4, the Tishchenko-Evans reaction for C5, and a chiral building block for C2.
키워드
aldol reaction; laidlomycin; monensin B; Tishchenko-Evans reaction; total synthesis; POLYETHER IONOPHORE ANTIBIOTICS; MEDIATED GROWTH-INHIBITION; CELL-CYCLE ARREST; CONVERGENT SYNTHESIS; CLAISEN REARRANGEMENT; MOLECULAR-STRUCTURE; ESTER ENOLATE; COMPLEX; BIS(TETRAHYDROFURAN); CONVERSION
- 제목
- Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
- 저자
- Kang, Sungkyoung; Lee, Wonchul; Jung, Byunghyuck; Lee, Hee-Seung; Kang, Sung Ho
- 발행일
- 2015-06
- 유형
- Article
- 권
- 4
- 호
- 6
- 페이지
- 567 ~ 572