양극성 정동장애 환자에서 valproate 사용 후 발생한가역성 파킨슨증 1예

초록

A Case of Reversible Parkinsonism Induced by Valproate in a Patient with Bipolar Disorder Kang-Uk Le, MD, PhD The author reports a case of reversible parkinsonism induced by valproate. The patient (61 years old male) with bipolar disorder developed typical parkinsonism from the initial period of valproate administration (dose：1500 mg, serum level：108.1 ug/mL)and disappeared rapidly after discontinuation of valproate. In psychiatric conditions such as bipolar disorder or other psychotic illnes, the possibility that the extrapyramidal sympoms be induced by valproate should be taken into careful consideration. In that case, carbamazepine can be recomended as a substitute medication. (Korean J Psychopharmacol 2004 ;15(1):107-111)

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