Identification and properties of 2,5-dihydroxy-4,3′-di(β-d-glueopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots

초록

2,5-Dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene was identified from Morus bombycis Koidzumi roots. The 2,5-dihydroxy-4,3'-di(P-D-glucopyranosyloxy)-trans-stilbene at a dose of 400-600mg/kg had hepatoprotective activity comparable to the standard agent, silymarin. The biochemical assays were confirmed by histological observations showing that the 2,5-dihydroxy-4,3'-di(P-D-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots decreased cell ballooning in response to CCI4 treatment. These results demonstrate that the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene component has a liver protective action against CCl4-induced hepatotoxicity. Copyright 0 2007 John Wiley & Sons, Ltd.

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