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초록
Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2'-hydroxy-3'-iodo-4',6'-dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of PGE(2) production from LPS-induced RAW 264.7 cells.
키워드
prenylated flavonoids; allylated chrysin analogues; vinylated chrysin analogues; anti-inflammatory activity; cyclooxygenase-2; PGE(2) production; Stille reaction; NITRIC-OXIDE PRODUCTION; FLAVONOIDS; RAW-264.7
- 제목
- Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues
- 저자
- Dao, TT; Oh, JW; Chi, YS; Kim, HP; Sin, KS; Park, H
- 발행일
- 2003-08
- 유형
- Article
- 권
- 26
- 호
- 8
- 페이지
- 581 ~ 584