Enhancement of Murine NK cell Activity in vitro by Red Ginseng Acidic Polysaccharide

초록

The in-vitro immunomodulatory function of the activity of murine natural-killer (NK) cells induced by redginsengacidic polysaccharide (RGAP) was examined. RGAP induced the significant enhancement of NK cell activityagainst the Yac-1 tumor cells. The treatment of splenocytes cultured with RGAP for 16 h resulted in a significant increasein NK activity at the E:T ratio of 100:1, and in a 239 and 250% increase at 10 and l00 μg/ml, respectively. We also demonstratethat RGAP treatment increased the production of interferon (IFN)-γ (17-125%) and tumor necrosis factor (TNF)-α (15-100%), suggesting that the increase in NK cell cytotoxicity could be due to the enhancement of the NK cell productionof both cytokines. In addition, RGAP had a stimulating effect on lymphocyte proliferation in the presence of mitogens. Overall, these results suggest that RGAP has an immunopotentiating effect on NK cells, which can support thedevelopment of clinical studies on RGAP.

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