상세 보기
Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells
- Weon, Jin Bae;
- Lee, Bohyoung;
- Yun, Bo-Ra;
- Lee, Jiwoo;
- Ma, Choong Je
Citations
WEB OF SCIENCE
6Citations
SCOPUS
8초록
Background: Cynanchum paniculatum, belongs to the family Asclepiadaceae and is used to treat various diseases, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time. Materials and Methods: 4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of C. paniculatum and its neuroprotective effect was evaluated by MTT assay. Results: 4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells. Conclusion: Furthermore, we found that reactive oxygen species (ROS) accumulation and calcium concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.
키워드
Cynanchum paniculatum; 4; 5-dimethoxypyrocatechol; HT22 cells; neuroprotective effect; OXIDATIVE STRESS; NEURODEGENERATIVE DISORDERS; NEURONAL CELLS; APOPTOSIS; GLUTAMATE; TOXICITY; DEATH; LINE
- 제목
- Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells
- 저자
- Weon, Jin Bae; Lee, Bohyoung; Yun, Bo-Ra; Lee, Jiwoo; Ma, Choong Je
- 발행일
- 2014-04
- 유형
- Article
- 권
- 10
- 호
- 38
- 페이지
- 161 ~ 164
- 언어
- ENG
- 출판사
- MEDKNOW PUBLICATIONS & MEDIA PVT LTD
- 발행국가
- 인도
- 분량
- 4 페이지
- ISSN
- E 0976-4062
P 0973-1296