Antimicrobial susceptibility pattern of Lawsonia intracellularis recently isolated from pig with proliferative hemorrhagic enteropathy in Korea

초록

The objective of this study was to determine the in vitro intracellular and extracellular minimum in-hibitory concentrations (MICs) of 13 antimicrobials against one recently isolate Lawsonia intracellularis, the etiological agent of proliferative enteropathy (PE). The final MICs were assessed by counting the number of heavily infected cells (HICs;＞30 bacteria per cell) using an immunoperoxidase monolayer assay. Enrofloxacin (InMIC; 1∼2 g/mL and ExMIC; 16 g/mL) still presented the most notable anti-microbial susceptibility, and marbofloxacin (2 g/mL and 8 g/mL) was followed. Colistin (0.25 g/mL and 2 g/mL) presented a susceptibility followed by tylvalosin (1 g/mL and 2 g/mL). Florfenicol and lincomycin had the weakest susceptibility and amoxicillin, penicillin G, chlortetracycline, oxytetracycline, tiamulin, tilmicosin, and tylosin displayed weak susceptibility. Although some antibiotics showed de-creased susceptibility patterns, they showed similar patterns to recent antibiotic susceptibility patterns in Korea. In addition, these results could be one of contributions in clinical fields.

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