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초록
Several 8-cycloalkoxychrysin analogs were synthesized from 6-benzyloxy-5,8-dihydroxyflavone and cycloalkanolsin 2 steps and we evaluated their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. Among tested analogs, two analogs with cyclopentyl substructure (796 and 798) showed strong inhibitory activity againstNO production.
키워드
chrysin; 8-cycloalkoxychrysin; anti-inflammatory; nitric oxide (NO)
- 제목
- 고리형 알콕시기를 함유한 크리신 유도체의 합성 및 일산화질소 생성 억제작용
- 제목 (타언어)
- Synthesis of 8-Cycloalkoxychrysin Analogs and their Inhibitory Activity Against NO Production
- 저자
- 김성수; 박해일
- 발행일
- 2015-02
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 59
- 호
- 1
- 페이지
- 12 ~ 16