Effects of additives on phase transitions of Poloxamer 407/Poloxamer 188 mixture and release property of monoolein cubic phase containing the poloxamers

초록

The gelling temperature of Poloxamer 407/Poloxamer 188 (16%/10%) mixture solution increased with increasing amount of surfactants. Among surfactants tested, the order of effectiveness in increasing the gelling temperature was sodium dodecyl sulfate (SDS) > tween 20 > cetyltrimethylammonium chloride (CTAC). The gelling temperature increased with the increasing concentration of cyclodextrin (CD). The order of effectiveness in increasing the gelling temperature was gamma CD > beta CD > alpha CD. The gelling temperature increased with increasing concentration of alcohols (ethanol and propylene glycol (PC)). On the contrary, dimethyl sulfoxide (DMSO) decreased the gelling temperature of P407/P188 (16%/10%) mixture solution. On the other hand, the gelling temperature decreased upon addition of NaCl but it increased by addition of MgCl2. With P407/P188-loaded monoolein cubic phase, the degrees of release in 40 hr were about 52% at 25 degrees C and 37.5% at 47 degrees C. The suppressed release at 47 degrees C is possibly because P407/P188 in the water channel of cubic phase is in gel state at the temperature. (C) 2011 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

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