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초록
Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against PGE_2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6-dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against PGE_2 and NO production than those of chrysin.
키워드
chrysin; 2-heteroaryl; anti-inflammatory; PGE_2; nitric oxide
- 제목
- 헤테로 고리를 갖는 크리신 유도체의 합성 및 항염증 작용에 대한 평가
- 제목 (타언어)
- Synthesis of Chrysin Analogs with a Heteroaryl Group and Evaluation for their Anti-inflammatory Activities
- 저자
- 박해일; 차해연; 트루옹넉투엔; 김현표
- 발행일
- 2011-12
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 55
- 호
- 6
- 페이지
- 462 ~ 465