Palladium-Catalyzed C-H Arylation Using Phosphoramidate as a Directing Group at Room Temperature

Chary, Bathoju Chandra; Kim, Sunggak; Park, Youngchul; Kim, Jinsik; Lee, Phil Ho

doi:10.1021/ol4009987

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Palladium-Catalyzed C-H Arylation Using Phosphoramidate as a Directing Group at Room Temperature

Chary, Bathoju Chandra;
Kim, Sunggak;
Park, Youngchul;
Kim, Jinsik;
Lee, Phil Ho

Citations

WEB OF SCIENCE

78

Citations

SCOPUS

78

초록

This communication describes the first phosphoramidate directing group for synthetically useful arylation. Remarkably, the nature of a new directing group drives selective C-H bond activation to afford diverse N-aryl phosphoramidates in good to excellent yields at room temperature.

키워드

ARYL HYDROGEN PHOSPHATES; BAYLIS-HILLMAN REACTION; N BOND FORMATION; CONVENIENT SYNTHESIS; COUPLING REACTIONS; ACTIVATION; ARENES; ACIDS; FUNCTIONALIZATION; ALKYNYLATION

제목: Palladium-Catalyzed C-H Arylation Using Phosphoramidate as a Directing Group at Room Temperature

저자: Chary, Bathoju Chandra; Kim, Sunggak; Park, Youngchul; Kim, Jinsik; Lee, Phil Ho

DOI: 10.1021/ol4009987

발행일: 2013-06-07

유형: Article

저널명: Organic Letters

권: 15

호: 11

페이지: 2692 ~ 2695