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초록
Militarin was isolated from Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom and reported to possess anticancer activities against several tumor cells. A number of militarin derivatives bearing different numbers of ethylene glycol unit were synthesized and evaluated for their biological activities related with anticancer and antiinflammatory effects. Among militarin derivatives tested, the compounds 2 and 5 exhibited anticancer and antiinflammatory activities.
키워드
militarin derivatives; anticancer activity; antiinflammatory activity; NO; iNOS; COX-2
- 제목
- 밀리타린 유도체의 합성 및 생리활성 평가
- 제목 (타언어)
- Synthesis and Biological Evaluation of Militarin Derivatives
- 저자
- 차해연; 박해일; 윤덕효; 김태웅; 성기호
- 발행일
- 2012-12
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 56
- 호
- 6
- 페이지
- 372 ~ 376