상세 보기
CONCISE SUBSTRATE-CONTROLLED ASYMMETRIC TOTAL SYNTHESIS OF (+)-3-(Z)-DIHYDRORHODOPHYTIN
- Kim, Byungsook;
- Sohn, Te-ik;
- Kim, Sanghee;
- Kim, Deukjoon;
- Lee, Jongkook
Citations
WEB OF SCIENCE
11Citations
SCOPUS
13초록
The first asymmetric total synthesis of (+)-3-(Z)-dihydrorhodophytin (1) has been accomplished in 15 steps in 17% overall yield from readily available starting material 6 in a substrate-controlled manner. Key steps in our synthesis are a highly stereoselective dianion alkylation for the synthesis of the alpha,alpha'-anti-RCM substrate and a strategy for the introduction of the chlorine function.
키워드
Total Synthesis; (+)-3-(Z)-Dihydrorhodophytin; Intermolecular Amide Enolate Alkylation; Ring-Closing Metathesis; Medium-Sized Oxacycle; ENANTIOSELECTIVE TOTAL-SYNTHESIS; STRATEGY; (+)-LAURENYNE; ALKYLATION; OXIDATION
- 제목
- CONCISE SUBSTRATE-CONTROLLED ASYMMETRIC TOTAL SYNTHESIS OF (+)-3-(Z)-DIHYDRORHODOPHYTIN
- 저자
- Kim, Byungsook; Sohn, Te-ik; Kim, Sanghee; Kim, Deukjoon; Lee, Jongkook
- 발행일
- 2011-03-01
- 유형
- Article
- 저널명
- Heterocycles
- 권
- 82
- 호
- 2
- 페이지
- 1113 ~ +
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- ISSN
- E 1881-0942
P 0385-5414